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KMID : 0604520080340020137
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Journal of the Society of Cosmetic Scientists of Korea
2008 Volume.34 No. 2 p.137 ~ p.142
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The Study on Tissue-Cultured Echinacea purpurea Adventitious Roots Extract for Application as a Cosmetic Ingredient
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Park Chang-Min
Joung Min-Seok
Choi Jong-Wan
Paek Kee-Yoeup
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Abstract
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Echinacea purpurea, an indian traditional plant medicine has been widely used as herbal remedy for the treatment of disease such as colds or other infections. However, Echinacea purpurea extracts recently have been applied as a cosmetic ingredient for skin care. We artificially cultured Echinacea purpurea by using the bioreactor culture system for this study. We induced callus from Echinacea purpurea and separated adventitious roots, harvested and extracted after cultured in bioreactors. Previously, several studies have been reported on anti-oxidant and immuno-enhancing effects of Echinacea purpurea extract but other efficacies were not well known. In this study, we investigated the whitening, anti-wrinkle and anti-oxidant effects to know applicable value of tissue-cultured Echinacea purpurea adventitious roots extract(TCEPARE) as a cosmetic ingredient. TCEPARE did not show cytotoxicity until a concentration of 2% and showed the anti-oxidative effect in DPPH and NBT tests. Also, the extract decreased tyrosinase expression in a dose-dependent manner and inhibited melanin synthesis in B16 melanoma cells. TCEPARE reduced protein levels of MMP-1, 2 secreted in culture medium or in cell lysates. From these results we suggest that TCEPARE has potential benefits applicable as to cosmetic ingredient for skin care products.
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KEYWORD
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Echinacea purpurea, whitening, anti-wrinkle, matrix metalloproteinase, B16 melanoma cell
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